The combination of niraparib and abiraterone halves the spread of prostate cancer in men with BRCA gene mutations.

Identification of variants influences treatment decisions. Inhibitors of the poly-ADP-ribose polymerase (PARP) system, a pathway for repairing single-stranded DNA breaks, are recommended for tumors ...

A powerful new drug combination—niraparib added to standard prostate cancer therapy—has been shown to significantly delay ...

This is a preview. Log in through your library . Abstract Homologous recombination is a key process for maintaining genome integrity and diversity. In eukaryotes, the nucleosome structure of chromatin ...

Scientists discovered four protein changes that help naked mole rats repair DNA faster. These small tweaks may explain their long lives.

Potential first-in-class, and industry-leading DNA polymerase Theta (Polθ) inhibitor, ART6043 demonstrated an attractive ...

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

A study reveals the secrets behind the rodent’s remarkable ability to live 10 times longer than expected, without cancer or ...

The protooncoprotein N-Myc, which is overexpressed in approximately 25% of neuroblastomas as the consequence of MYCN gene amplification, has long been postulated to regulate DNA double-strand break ...