Researchers found that losing a second protein, FIGNL1, allows cancer cells missing BRCA2 to restore DNA repair by reloading ...

New research from the University of Wisconsin–Madison reveals that dysfunction in a protein essential to maintaining ...

Cells contain a blueprint in the form of DNA that dictates what they can make. This blueprint is converted into a message ...

aThe Cardiac Exercise Research Group at the Faculty of Medicine and Health Sciences, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway ...

Potential first-in-class, and industry-leading DNA polymerase Theta (Polθ) inhibitor, ART6043 demonstrated an attractive tolerability profile, expected PK/PD activity, and promising clinical signals ...

Immune checkpoint inhibitors are well known as a form of cancer treatment. Researchers at UZH have now identified a new, important function of these inhibitors: promotion of tissue healing. This ...

Spinal cord injury (SCI) presents a significant clinical challenge due to its complex pathology and limited capacity for self-repair, often resulting in substantial physical dysfunction. Conventional ...

Department of Orthopedics, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China Sarcopenia is a major health issue among the global aging population, with ...

Naked mole-rats are one of nature's most extraordinary creatures. These burrowing rodents can live for up to 37 years, around ten times longer than relatives of a similar size. But what is the secret ...

Using comparative molecular biology with human cGAS – which actually inhibits DNA repair – the scientists found that the naked mole-rat's enzyme has four key changes that facilitate the important work ...

One of nature’s strangest animals may hold the secret to living a long life, scientists have revealed. The naked mole rat may not be known for its good looks, but the bald rodent has long been ...